doi:10.1093/nsr/nwab193, 14. Third, because of limited resources, we could not perform pseudo-virus neutralization tests of neutralizing antibodies against COVID-19 (27). Vaccines are safe and effective at lowering the risk of getting sick and dying from COVID-19. A total of 1,350 serum samples were collected from 595 participants (Figure1), of whom 457 (76.8%) were medical staff and 138 (23.2%) were workers of the Henan Electric Power Exploration Company in central China. We dont know why people with Type O might possibly be more protectedbut there are a lot of theories. Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and -experienced subjects: Impact of booster dose and breakthrough infections. Unauthorized use of these marks is strictly prohibited. This content includes information from experts in their field and is fact-checked to ensure accuracy. If youre type O, you naturally make antibodies against Type A and Type B, Dr. Udden says. Bookshelf The clots may also form in multiple places in the body, including in the lungs. Except for blood type, all demographic and baseline characteristics were balanced between the intervention and control groups (Table1). The full eligibility criteria were provided in the volunteer recruitment notification distributed through social networks, including WeChat groups. The levels of IFN- and CD4+ T-lymphocytes were not altered in the participants for 240 days after vaccination, whereas the levels of neutralizing antibodies, B-lymphocytes, and IL-6 decreased with increasing time after vaccination. Following vaccination, the participating medical staff of Henan Provincial Peoples Hospital and Zhengzhou Municipal Traditional Medicine Hospital, and workers of the Henan Electric Power Exploration Company in central China were followed up monthly for 8 months between June 19, 2021, and April 30, 2022. That year, research in the journal .css-16acfp5{-webkit-text-decoration:underline;text-decoration:underline;text-decoration-thickness:0.125rem;text-decoration-color:#d2232e;text-underline-offset:0.25rem;color:inherit;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}.css-16acfp5:hover{color:#000;text-decoration-color:border-link-body-hover;background-color:yellow;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}PLOS Genetics revealed that people with Type A blood are more likely to have a severe case of Covid-19. IntroductionIn China, the long-term immunogenicity and adverse effects of inactivated vaccines produced by different or the same manufacturer remain unclear. Not everyone gets side effects. 2021;2(9):709056. doi:10.3389/fpubh.2021.709056 The original contributions presented in the study are included in the article/Supplementary Material. Figure3 Quantitation of cell immune responses on days 1240 following administration of the Chinese inactivated vaccine. The worst outcome of these side effects is associated with VST, why it should not be missed and treated appropriately in due time. . BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: A prospective, single-centre, longitudinal cohort study in health-care workers. Opens in a new tab or window, Visit us on Instagram. World J Clin Cases. Keywords: These fun facts about everything from the cosmos to the inner workings of your body will blow your mind. The multiple linear regression analysis revealed that participants aged >50 years had lower reactive IFN- levels and B-lymphocyte counts than those aged 1830 years (Tables36, Figures3AG; Tables S8S15) (B = 0.15, p = 0.03; B = 0.04, p = 0.036, respectively) (Tables3, 5; Figures3A, D). Julita Mir, M.D., Infectious Disease Physician and . by Researchers have been talking about blood type and COVID-19 susceptibility for months. BMI, body mass index; LSMD, least-square mean difference. The Public Health Agency of Canada, Health Canada, and provincial and territorial health authorities continue to: Doctors aren't yet sure if there is a link between the . In the case of the two mRNA COVID-19 vaccines, well over 90% of . All authors contributed to the article and approved the submitted version. In contrast, we observed a decrease in the B-lymphocyte count and IL-6 level on days 1 to 240 in participants stimulated with the SARS-CoV-2 S antigen (B = 0.004, 95% CI 0.005 to 0.003; p = 0.008 and B = 0.004, 95% CI 0.006 to 0.002, p = 0.001, respectively; Tables5, 6; Figures3A, G). But VWF also encourages clotting. The American Red Cross reports that 8 percent of white Americans, 4 percent of African-Americans, 4 percent of Latinx-Americans, and 1 percent of Asian-Americans are O-negative. At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. Whether mild or severe, data from the U.S. Centers for Disease Control and Prevention (CDC), has shown that women are bearing the brunt of vaccine reactions, and experts believe it may be due to . This can progress to affect the rest of the body and cause. Acute disseminated encephalomyelitis following the COVID-19 vaccine Ad26.COV2.S, a case report. They looked at both how likely a patient was to contract COVID-19, and how likely they were to become seriously ill (or even die) from it if they did. Follow-up visits were scheduled on days 130 to measure vital signs, review any solicited and unsolicited adverse events, and update medical and medication records. Blood type O seems to have the lowest risk. Parums DV. This type of side effect most commonly occurs within the first hour of when the vaccine is given and usually immediately after. We dont know about asymptomatic carriersthat is, Type O could still pass along the virus to other people unknowingly just as much as Type A could. Either way, that would color how likely you are to not only get the virus but also how strong your symptoms are, he explains. Environ Res (2022) 215:114131. doi:10.1016/j.envres.2022.114131, 3. (AC) Kinetics of interferon-gamma levels according to (A) age, (B) blood type, and (C) occupation. These include soreness where the jab was. doi:10.1016/j.jclinepi.2021.12.015, 4. But now, there's finally some good news for a third of Americans. Copyright 2023 Yuan, Xu, Ma, Chen, Wang, Wang, Jing, Zhang, Wang, Yan, Zhang, Zhao and Li. Anderson disclosed no relevant relationships with industry. Among those who had COVID-19, hospitalization and ICU admission was associated with male sex and age. Share on Facebook. Then, a study published in the New England Journal of Medicine confirmed the idea with a peer-reviewed study: Folks with Type A blood were 45 percent more likely to become infected with Covid than those with other blood types, while those with Type O were 35 percent less likely. Antibody responses to BNT162b2 vaccination in Japan: Monitoring vaccine efficacy by measuring IgG antibodies against the receptor-binding domain of SARS-CoV-2. And for more signs you could've contracted the virus, check out If You Have This Symptom, There's an 80 Percent Chance You Have COVID. Researchers in China first shared this idea in March 2020, and the findings were echoed by a paper out of Columbia University a month later. } We also evaluated CD4+ T-lymphocyte counts, B-cell counts, and IFN- and IL-6 levels after stimulation with the S protein of SARS-CoV-2 in 543, 539, 513, and 512 individuals, respectively. Those who are O-negative may be the least likely to get COVID. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. 2021 Sep 2;17(9):2957-2958. doi: 10.1080/21645515.2021.1922061. "It's pretty clear that Type O is protective to some degree. Negative blood types are also somewhat protected from the virus. To analyze the changes in neutralizing antibodies and cellular immune responses over time, we used a mixed linear model with continuous natural log10-transformed cellular immune response data or the log2-transformed concentration of neutralizing antibodies against SARS-CoV-2 spike protein between days 1 and 240 as the dependent variable; age, sex, body mass index (BMI), occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood were included as covariates in the models. When a vaccine is injected, the body's immune response jumps into action, responding to the presence of a foreign entity. In addition, we are grateful to our colleagues Wenning Yang, Yafei Chu, Qiong Ma, and Wenbo Xu, who assisted with sample collection. But recently, the genetics company 23andMe revealed preliminary data from their own study showing that a person's blood type, which is determined by the ABO gene, appears to affect susceptibility to coronavirus. This can begin anywhere from a few minutes to a few hours after the injection. Opens in a new tab or window, Visit us on Facebook. "Or by being Type O, the virus gets in but the A antibody prevents it from docking with enough cells to cause disease. Participants in the mixed-manufacturer vaccination group, those with an interval of >40 days between doses of vaccination, and workers produced lower levels of IL-6 than those in the same-manufacturer vaccination group, those with an interval of <40 days between doses of vaccination, and medical staff (B = 0.01, 95% CI 0.014 to 0.003, p = 0.003, B = 0.44, 95% CI 0.8 to 0.1, p = 0.019, and B = 1.5, 95% CI 2.1 to 0.9, p < 0.001, respectively; Table6; Figures3FH). Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. In conclusion, safety concerns against SARS-CoV-2 vaccines are backed by an increasing number of studies reporting neurological side effects. April 5, 2021. However, the incidence of fever, injection site pain, and malaise in the mixed-manufacturer vaccination group was slightly but significantly (p < 0.01) higher (1/143, 0.71%) than in the same-manufacturer vaccination group (1/425, 0.28; Figure2F). doi: 10.6061/clinics/2021/e3286. Exacerbating GuillainBarr syndrome eight days after vectorbased COVID19 vaccination. But both docs agree it shouldnt actually change anyones behavior. "Up to 10 percent of people who have COVID experience side effects such as . -, Wiedmann M, Skattr T, StrayPedersen A, et al. Congestion/runny nose. A review of neurological side effects of COVID-19 vaccination. BM, GC, and ZW contributed to the collection and interpretation of the laboratory and clinical data. Acta Neurol Scand. Wang L, Fan JP, Xu Y, Wang JL, Wang MZ. A new study has good news for more than a third of Americans. Once a vaccine goes into your arm, your blood flow increases and immune cells rush to the scene. Lancet Respir Med (2021) 9:9991009. Epub 2021 Aug 28. Nausea. 20052022 MedPage Today, LLC, a Ziff Davis company. Associations between blood type and COVID-19 infection, intubation, and death. The following outcomes were selected and defined by the authors based on information from regulatory authorities, previous studies, large-scale adverse events initiatives: febrile seizure, aseptic. var xhr = new XMLHttpRequest(); Lancet (2022) 399:5219. "The smaller sample sizes and retrospective, observational nature of many prior studies, in addition to their striking heterogeneity of ABO associations with disease susceptibility and severity, could be due to chance variations, publication bias, differences in genetic background, geography and environment, and viral strains," they wrote. Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: A sentinel surveillance study. We only observed a trend of decreasing neutralizing antibodies after vaccination over time. Latest research and advice on side effects and allergic reactions related to COVID-19 vaccines. Online ahead of print. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. "Blood group O is significantly associated with reduced susceptibility to SARS-CoV-2. Immunol. Table4 Factors associated with CD4+ T-lymphocyte count after the administration of the Chinese inactivated COVID-19 vaccine. Type O blood, the most common in the U.S., provides some protection against COVID. Second, the reported adverse events could also have been underestimated due to the small number of participants and short observation period. Shaw AT, Bauer TM, de Marinis F, Felip E, Goto Y, Liu G, et al. Experts say more . Brand of vaccine administered (Moderna or Pfizer-BioNTech) and the change in average blood glucose, peak blood glucose, and percentage of time spent in normal range as well as above average range of blood glucose level following vaccine administration will be assessed. On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group . However, in China, data on long-term immunogenicity and adverse effects of inactivated vaccines produced by different manufacturers or the same manufacturer have not been reported. Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. He had personal struggles during a life-changing year. Socio-economic status is a big vulnerability, and age and health are next in line for susceptibility. Participants with a clinically notable acute illness or a body temperature of at least 38C within 24h before receiving the planned dose of the study vaccine, clinical manifestations compatible with those of COVID-19, and any condition that contraindicates or discourages the administration of an inactivated vaccine, including pregnancy, were excluded (15). And for more regular updates on the virus, sign up for our daily newsletter. Lancet Infect Dis (2022) 22:47382. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Before Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). Finally, individuals with certain occupations, including workers, especially older individuals and men, had low levels of antibodies and had weakened cellular immune responses following the second dose compared to their counterparts, suggesting that a longer gap between vaccine doses, which is a strategy in effect in some countries, should be re-evaluated, especially for more susceptible populations. Patients were aged 25 to 63 years, had PNH granulocyte clones of 80%, and had not received transfusions in the past year. For a March study out of the Southern University of Science and Technology in Shenzhen, China, scientists tracked the blood types of nearly 2,200 COVID-19 patients in Chinese hospitals, along with those of about 27,000 individuals who didn't have COVID-19 in the same areas. Amyloid -related angiitis of the central nervous system occurring after COVID-19 vaccination: A case report. Bruising for no. (EG) Kinetics of interferon (IL)-6 levels according to (E) age, (F) vaccine manufacturer, (G) occupation and (H) interval between doses of vaccination. Serious side effects. COVID vaccines and safety: what the research says. J Clin Epidemiol (2022) 144:16372. Lorsque vous utilisez nos sites et applications, nous utilisons des, authentifier les utilisateurs, appliquer des mesures de scurit, empcher les spams et les abus; et. Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). People may start . Eur J Med Res. Whether the immunogenic response observed in this study will translate to better efficacy and effectivenessa fact that should be considered in strategic decisions about vaccination programsis unknown. and transmitted securely. 2021;30(12):721146. doi:10.3389/fneur.2021.721146 ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. Front Immunol (2022) 13:863554. doi:10.3389/fimmu.2022.863554, 25. A retrospective analysis of clinically confirmed long post-COVID vaccination syndrome. Based on the duration after vaccination of the participants, we divided the duration after vaccination of the participants into eight groups: 114, 1530, 3060, 6190, 91120, 121150,151180, and 181240 days. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. Fatigue, headaches, muscle and joint aches and fever are all potential side effects as well. In fact, the findings suggest that people with blood type A face a 50 percent greater risk of needing oxygen support or a ventilator should they become infected with the novel coronavirus. We may earn a commission through links on our site. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. Natl Sci Rev (2021) 8:nwab193. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Si vous souhaitez personnaliser vos choix, cliquez sur Grer les paramtres de confidentialit. National Library of Medicine In 2020, scientists started talking about a link between blood type and Covid. dvelopper et amliorer nos produits et services. COVID19 vaccination acceptance among healthcare workers and nonhealthcare workers in China: a survey. Immune responses to the heterologous vaccination schedule were within the range of those reported using homologous schedules. Boosting vaccination is considered important, as antibodies and cellular immune responses were reduced in susceptible populations. There's no known connection between blood types and side effects from COVID-19 vaccines. sharing sensitive information, make sure youre on a federal Lancet Respir Med (2022) 10:73948. Data are presented as mean (95% confidence interval [CI]) from the linear mixed-effects model adjusted for vaccine manufacturer, sex, blood type, age, occupation, and BMI. It is COVID infection, and the growing evidence of persistent symptoms from what has become known as "long COVID," that are the most troubling unknown out there, Goepfert says. Safety of COVID-19 Vaccines Some people have no side effects. Pour en savoir plus sur la faon dont nous utilisons vos donnes personnelles, veuillez consulter notre politique relative la vie prive et notre politique en matire de cookies. Progress and challenge of COVID-19 vaccine development. Participants with blood type A had lower levels of neutralizing antibodies than those with blood type B during 114 days after vaccination (least-square mean difference = 15.8, 95% CI 11.025.2; p = 0.044) (Table S2). J Neuroimmunol. 30. U.S. federal health agencies have recommended pausing the use of Johnson & Johnson's COVID-19 vaccine after six recipients developed a rare disorder involving blood clots, in a fresh setback to . xhr.open('POST', 'https://www.google-analytics.com/collect', true); The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). METHODOLOGY A cross-sectional study was carried out, in which . "There's a fairly decent amount of existing literature beyond SARS-CoV-2" that certain blood types can play a role in disease risk and severity, says Joel Ray, M.D., a clinician scientist and professor at St. Michael's . By February 21, 2021, more than 46 million persons received at least 1 dose of an mRNA-based COVID-19 vaccine. MeSH Of the 107,796 individuals tested for COVID-19, 11,468 patients tested positive. Since both of those types are fairly rare, the Red Cross works hard to . doi:10.1080/14760584.2021.1971523, 13. However, this speculation requires validation using a larger patient cohort. Yin F, Wu Z, Xia X, Ji M, Wang Y, Hu Z. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): A phase 4, non-inferiority, single blind, randomised study. Four types of COVID-19 vaccine have been approved for use worldwide: mRNA, inactivated virus, adenovirus, and recombinant protein vaccines (11). 2022 Dec 6;10(34):12617-12622. doi: 10.12998/wjcc.v10.i34.12617. doi:10.2196/26089, 24. Use or keep moving your arm. It's normal to experience side effects after the vaccine. Table6 Factors associated with IL-6 level after the administration of the Chinese COVID-19 inactivated vaccine. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. Although not all of these side effects may occur, if they do occur they may need . One study published by the CDC reports that from March 2020 to January 2021, patients with COVID-19 had nearly 16 times the risk for myocarditis compared with patients who did not have COVID-19. doi:10.12659/MSM.938532, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. N Engl J Med (2020) 383:201829. Those four main blood groupsA, AB, B, and Ocan be Rh-positive or Rh-negative, meaning that there are 8 blood groups in total. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. The full coverage rate of the COVID-19 vaccination program has reached approximately 90% of the population required to be vaccinated in 2022 (10). (19, 20), we divided participants into three BMI groups: <18.5, 18.523.9, and >23.9 kg/cm2. As with all vaccines, side effects may occur after getting the COVID-19 vaccine. An independent data-monitoring committee, comprising independent scientists not involved in this study, has been reviewing the data regularly for safety and scientific integrity. The most common adverse effect was fatigue (n = 4), followed by fever (n = 2), injection site pain (n = 4), malaise (n = 4), rash (n = 4), and pruritus (n = 3). Blood type doesnt affect much in our daily lives. Vaccine (2021) 39:114856. Moderna says 9.7% of their participants felt fatigued and 4.5% got . 04:20. Reactogenicity analysis results are presented as percentage of participants. Opens in a new tab or window, Visit us on Twitter. She is a 2020 J2 Achievement Award winner for her COVID-19 coverage. This weird trivia you didn't know about the world will blow you away. Please enable it to take advantage of the complete set of features! Vaccines are still important, as are smart choices to protect yourself from germs. Association between mRNA vaccination and COVID-19 hospitalization and disease severity. The researchers at St. Michael's Hospital in Toronto, Canada, examined the test results of 225,556 Canadians who had been tested for COVID-19 between Jan. 15 and Jun. Other neurological side effects occur in a much lower frequency. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Wong MCS, Wong ELY, Huang J, Cheung AWL, Law K, Chong MKC, et al. The levels of neutralizing antibodies and IFN- were higher in medical staff 240 days after vaccination than in workers. Finsterer J. People with Type O blood might be slightly more protected from the virus, and people with Type A slightly more vulnerable. The two tubes with the EDTA anticoagulant were used to determine lymphocyte subsets with or without antigen-stimulated SARS-CoV-2 spike peptides, and the two tubes without the EDTA anticoagulant were used to determine neutralizing antibodies against SARS-CoV-2 and cytokines with or without antigen-stimulated SARS-CoV-2 spike peptides. But the virus is still in your system and you can still pass it to someone else.". Bull Natl Res Cent. According to a CDC study which analyzed the first month of vaccinations, more than 79% of side effects were reported by women, even though women only accounted for 60% of vaccinations given.. Opens in a new tab or window, Visit us on YouTube. Prospective cohort of Chinese individuals immunized with the inactivated vaccine and serological assays. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. Front Public Health. Nous, Yahoo, faisons partie de la famille de marques Yahoo. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.
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